Wyniki prologu z dnia 02.06.2010, Luxembourg, dystans 2,659 km
| 1 | Jimmy Engoulvent (Fra) Saur-Sojasun | 0:03:41.990 | |
| 2 | Cyril Lemoine (Fra) Saur-Sojasun | 0:00:08.140 | |
| 3 | Grégory Rast (Swi) Team Radioshack | 0:00:08.230 | |
| 4 | Jimmy Casper (Fra) Saur-Sojasun | 0:00:09.010 | |
| 5 | Lance Armstrong (USA) Team Radioshack | 0:00:09.110 | |
| 6 | Daryl Impey (RSA) Team Radioshack | 0:00:10.490 | |
| 7 | Borut Bozic (Slo) Vacansoleil Pro Cycling Team | 0:00:10.680 | |
| 8 | Aitor Galdos (Spa) Euskatel – Euskadi | 0:00:10.810 | |
| 9 | Andreas Klöden (Ger) Team Radioshack | 0:00:12.380 | |
| 10 | Jempy Drucker (Lux) Continental Team Differdange | ||
| 11 | Kevin Ista (Bel) Cofidis | 0:00:13.500 | |
| 12 | Giovanni Visconti (Ita) ISD-Neri Cycling Team | 0:00:13.090 | |
| 13 | Gorka Izaguirre (Spa) Euskatel – Euskadi | 0:00:14.120 | |
| 14 | Sandy Casar (Fra) Francaise Des Jeux | 0:00:14.026 | |
| 15 | Jonathan Castroviejo (Spa) Euskatel – Euskadi | 0:00:14.230 | |
| 16 | Serguei Ivanov (Rus) Katusha Cycling Team | 0:00:14.410 | |
| 17 | Björn Leukemans (Bel) Vacansoleil Pro Cycling Team | 0:00:14.480 | |
| 18 | Juan Antonio Flecha (Spa) Team Sky | 0:00:14.080 | |
| 19 | Martin Mortensen (Den) Vacansoleil Pro Cycling Team | 0:00:15.360 | |
| 20 | Matteo Carrara (Ita) Vacansoleil Pro Cycling Team | 0:00:15.730 | |
| 21 | Patrick Sinkewitz (Ger) ISD-Neri Cycling Team | ||
| 22 | Simon Gerrans (Aus) Team Sky | 0:00:16.120 | |
| 23 | Freddy Bichot (Fra) Bbox Bouygues Telecom | 0:00:16.620 | |
| 24 | Koen De Kort (Ned) Skil – Shimano | 0:00:16.660 | |
| 25 | Fränk Schleck (Lux) Team Saxo Bank | 0:00:16.850 | |
| 26 | Robert Retschke (Ger) Continental Team Differdange | 0:00:16.980 | |
| 27 | Frederik Wilmann (Nor) Skil – Shimano | 0:00:17.300 | |
| 28 | Jérémy Roy (Fra) Francaise Des Jeux | 0:00:17.400 | |
| 29 | Tony Gallopin (Fra) Cofidis | 0:00:17.510 | |
| 30 | Sam Bewley (NZl) Team Radioshack | 0:00:17.070 | |
| 31 | Pawel Brutt (Rus) Katusha Cycling Team | ||
| 32 | Mathieu Sprick (Fra) Bbox Bouygues Telecom | 0:00:18.150 | |
| 33 | Alexandre Geniez (Fra) Skil – Shimano | 0:00:18.230 | |
| 34 | Nico Sijmens (Bel) Cofidis | 0:00:18.340 | |
| 35 | Christian Poos (Lux) Continental Team Differdange | 0:00:18.370 | |
| 36 | Mitchell Docker (Aus) Skil – Shimano | 0:00:18.450 | |
| 37 | Matic Strgar (Slo) Vorarlberg-Corratec Cycling Team | 0:00:18.530 | |
| 38 | Dirk Bellemakers (Ned) Landbouwkrediet – Colnago | 0:00:18.700 | |
| 39 | Juan Javier Estrada Ruiz (Spa) Andalucia Cajasur | 0:00:18.940 | |
| 40 | Björn Selander (USA) Team Radioshack | 0:00:19.110 | |
| 41 | Michal Golas (Pol) Vacansoleil Pro Cycling Team | ||
| 42 | Piergiorgio Camussa (Ita) Vorarlberg-Corratec Cycling Team | 0:00:19.240 | |
| 43 | Ruben Perez (Spa) Euskatel – Euskadi | 0:00:19.530 | |
| 44 | Brice Feillu (Fra) Vacansoleil Pro Cycling Team | 0:00:19.830 | |
| 45 | Cyril Bessy (Fra) Saur-Sojasun | 0:00:20.150 | |
| 46 | Yukihiro Doi (Jpn) Skil – Shimano | 0:00:20.870 | |
| 47 | Jens Voigt (Ger) Team Saxo Bank | 0:00:21.250 | |
| 48 | Yohann Gene (Fra) Bbox Bouygues Telecom | ||
| 49 | Kim Kirchen (Lux) Katusha Cycling Team | 0:00:21.270 | |
| 50 | Aitor Hernandez (Spa) Euskatel – Euskadi | 0:00:21.320 | |
| 51 | Romain Matheou (Fra) Saur-Sojasun | 0:00:21.450 | |
| 52 | Carlo Scognaniglio (Ita) ISD-Neri Cycling Team | 0:00:21.460 | |
| 53 | Angel Vivioso Arcos (Spa) Andalucia Cajasur | 0:00:21.650 | |
| 54 | Franck Bouyer (Fra) Bbox Bouygues Telecom | 0:00:22.300 | |
| 55 | Sébastien Turgot (Fra) Bbox Bouygues Telecom | 0:00:22.400 | |
| 56 | Manuel Ortega Ocana (Spa) Andalucia Cajasur | 0:00:22.610 | |
| 57 | Alexander Kolobnev (Rus) Katusha Cycling Team | 0:00:22.650 | |
| 58 | Sebastian Siedler (Ger) Vorarlberg-Corratec Cycling Team | 0:00:22.720 | |
| 59 | Tiago Machado (Por) Team Radioshack | 0:00:22.760 | |
| 60 | Romain Zingle (Fra) Cofidis | 0:00:22.800 | |
| 61 | Dominic Klemme (Ger) Team Saxo Bank | 0:00:22.960 | |
| 62 | Arnaud Labbe (Fra) Cofidis | 0:00:23.600 | |
| 63 | Anthony Charteau (Fra) Bbox Bouygues Telecom | 0:00:23.640 | |
| 64 | Gianni Meersman (Fra) Francaise Des Jeux | 0:00:24.210 | |
| 65 | Cédric Coutouly (Fra) Saur-Sojasun | 0:00:24.310 | |
| 66 | Ivan Rovny (Rus) Team Radioshack | 0:00:24.390 | |
| 67 | Rony Martias (Fra) Saur-Sojasun | 0:00:24.430 | |
| 68 | Serge Pauwels (Bel) Team Sky | 0:00:24.570 | |
| 69 | Kjell Carlstrom (Fin) Team Sky | 0:00:24.590 | |
| 70 | Anthony Roux (Fra) Francaise Des Jeux | 0:00:24.650 | |
| 71 | Danilo Napolitano (Ita) Katusha Cycling Team | 0:00:24.700 | |
| 72 | Kurt Arvesen (Nor) Team Sky | 0:00:25.120 | |
| 73 | Eduard Vorganov (Rus) Katusha Cycling Team | 0:00:25.150 | |
| 74 | Laurent Didier (Lux) Team Saxo Bank | 0:00:25.240 | |
| 75 | Hakan Nilsson (Swe) Continental Team Differdange | 0:00:25.280 | |
| 76 | Alexandre Pichot (Fra) Bbox Bouygues Telecom | 0:00:25.510 | |
| 77 | Sergey Lagutin (Uzb) Vacansoleil Pro Cycling Team | 0:00:25.530 | |
| 78 | Koen Barbe (Bel) Landbouwkrediet – Colnago | ||
| 79 | Frédéric Guesdon (Fra) Francaise Des Jeux | 0:00:25.620 | |
| 80 | Bart Dockx (Bel) Landbouwkrediet – Colnago | 0:00:25.720 | |
| 81 | Paolo Longo Borghini (Ita) ISD-Neri Cycling Team | 0:00:25.800 | |
| 82 | Sébastine Delfosse (Bel) Landbouwkrediet – Colnago | 0:00:25.820 | |
| 83 | Silvere Ackermann (Swi) Vorarlberg-Corratec Cycling Team | 0:00:25.098 | |
| 84 | Clemens Fankhauser (Aut) Vorarlberg-Corratec Cycling Team | 0:00:26.160 | |
| 85 | Alex Rasmussen (Den) Team Saxo Bank | 0:00:26.170 | |
| 86 | Bert Scheirlinckk (Bel) Landbouwkrediet – Colnago | 0:00:26.270 | |
| 87 | Oscar Gatto (Ita) ISD-Neri Cycling Team | 0:00:26.590 | |
| 88 | Bartozs Huzarsky (Pol) ISD-Neri Cycling Team | 0:00:26.800 | |
| 89 | Vytautas Kaupas LIT Continental Team Differdange | 0:00:27.470 | |
| 90 | Johnny Hoogerland (Ned) Vacansoleil Pro Cycling Team | 0:00:27.490 | |
| 91 | Ian Stannard (GBr) Team Sky | 0:00:27.610 | |
| 92 | Thomas Lofkvist (Swe) Team Sky | 0:00:27.700 | |
| 93 | Arthur Vichot (Fra) Francaise Des Jeux | 0:00:28.140 | |
| 94 | Nikita Eskov (Rus) Katusha Cycling Team | 0:00:28.240 | |
| 95 | Fabrice Jeandesboz (Fra) Saur-Sojasun | 0:00:28.300 | |
| 96 | Saïd Haddou (Fra) Bbox Bouygues Telecom | 0:00:28.800 | |
| 97 | Alexandr Pliuschin (Mda) Katusha Cycling Team | 0:00:29.010 | |
| 98 | Morten Knudsen (Den) Continental Team Differdange | ||
| 99 | Nico Schneider (Ger) Continental Team Differdange | 0:00:29.780 | |
| 100 | Cristophe Sokoll (Aut) Vorarlberg-Corratec Cycling Team | 0:00:29.880 | |
| 101 | Mikel Nieve (Spa) Euskatel – Euskadi | 0:00:30.270 | |
| 102 | Guillaume Blot (Fra) Cofidis | 0:00:30.330 | |
| 103 | Tristan Valentin (Fra) Cofidis | 0:00:31.280 | |
| 104 | Steve Houanard (Fra) Skil – Shimano | 0:00:31.050 | |
| 105 | Ben Swift (GBr) Team Sky | 0:00:31.640 | |
| 106 | Yoann Offredo (Fra) Francaise Des Jeux | 0:00:31.800 | |
| 107 | Sergio De Lis (Spa) Euskatel – Euskadi | 0:00:33.810 | |
| 108 | Stefan Cohen (Ned) Continental Team Differdange | 0:00:34.900 | |
| 109 | Tom Van Den Haute (Bel) Landbouwkrediet – Colnago | 0:00:34.970 | |
| 110 | Jorge Martin Montenegro (Arg) Andalucia Cajasur | 0:00:35.140 | |
| 111 | Floris Goesinnen (Ned) Skil – Shimano | 0:00:36.360 | |
| 112 | Kasper Klostergaard (Den) Team Saxo Bank | 0:00:36.380 | |
| 113 | Miguel Minguez (Spa) Euskatel – Euskadi | 0:00:36.070 | |
| 114 | Davide Ricci Bitti (Ita) ISD-Neri Cycling Team | 0:00:37.210 | |
| 115 | Yauheni Hutarovich (Blr) Francaise Des Jeux | 0:00:37.730 | |
| 116 | Javier Ramirez Abeja (Spa) Andalucia Cajasur | 0:00:38.140 | |
| 117 | Antonio Piedra Perez (Spa) Andalucia Cajasur | 0:00:38.270 | |
| 118 | Steven Caethoven (Bel) Landbouwkrediet – Colnago | 0:00:38.310 | |
| 119 | Ruslan Pidgornyy (Ukr) ISD-Neri Cycling Team | 0:00:40.530 | |
| 120 | Kevin Neirynck (Bel) Landbouwkrediet – Colnago | 0:00:42.330 | |
| 121 | Manuel Calvente Corpas (Spa) Andalucia Cajasur | 0:00:42.920 | |
| 122 | Alexander Gufler (Ita) Vorarlberg-Corratec Cycling Team | 0:00:43.010 | |
| 123 | Antonio Cabello Baena (Spa) Andalucia Cajasur | 0:00:44.210 | |
| 124 | Thierry Hupond (Fra) Skil – Shimano | 0:05:17.010 |
